치주염 조직에서 발현이 증가하는 CTGF에 의한 파골세포 생존 증가
Increased Expression of CTGF in Periodontitis Tissue and Its Role for Enhanced Mature Osteoclast Survival
한혜련, 박종철, 유미현, 배문경, 김형준,
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한혜련 ( Han Hye-Yeon ) - 부산대학교 치의학전문대학원 구강병리학교실
박종철 ( Park Jong-Cheol ) - 부산대학교 치의학전문대학원 구강악안면외과학교실
유미현 ( Ryu Mi-Heon ) - 부산대학교 치의학전문대학원 구강병리학교실
배문경 ( Bae Moon-Kyung ) - 부산대학교 치의학전문대학원 구강생리학교실
김형준 ( Kim Hyung-Joon ) - 부산대학교 치의학전문대학원 구강생리학교실
Abstract
Connective tissue growth factor (CTGF, CCN2) is one of the multi-functional secreted proteins which belong to CCN family of cysteine-rich growth factors. CTGF is known to have pivotal roles in embryonic endochondral ossification but its role in relevance to periodontitis is never been determined. To identify new molecular mediators associated with periodontitis-induced bone resorption, we have analyzed publicly available GEO database and found the markedly augmented CTGF mRNA expression in periodontitis gingival tissues. The existence of CTGF significantly enhanced mature osteoclasts survival which accompanied by reduction in TUNEL-positive nuclei and PARP cleavage. These results may provide another line of evidence the CTGF mediated prolonged osteoclast survival and subsequent increased bone resorption in the periodontitis patients.
키워드
Periodontitis; CTGF; Osteoclast; Bone resorption
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